Previous studies using the taste conditioning procedure have shown that B6 and D2 mice also differ in the taste sensitivity to alcohol (Risinger and Cunningham, 1995). Quantitative train locus (QTL) analyses in different strains of mice, including B6 and D2, have identified several chromosomal regions containing genes that may play a role in the development of alcohol-induced conditioned taste aversion (Risinger and Cunningham, 1998). These studies found taste conditioning QTLs on different chromosomes, including chromosome 7 that encode CHRM2. These finding are consistent with differences in cholinergic function between B6 and D2 mice (Imperato et al., 1996). Evidence of significant linkage and association between frontal theta ERO power and CHRM2 has also been shown in humans (Jones et al., 2004, 2006b). However, the relationship among cortical ERO energy, alcohol taste and CHRM2 in B6 and D2 mice is still unclear. Findings from the present study showed that baseline ERO energy in the frontal alpha/beta band and in the parietal delta, theta and alpha/beta bands were significantly reduced in B6 mice, compared to D2 mice. Studies have shown behavioral differences between
