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Chunk #3 — METHODS SUMMARY

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Genes mirror geography within Europe.
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The new assignment method used here is based on independent linear models for latitude and longitude where each is predicted jointly by PC1 and PC2, including quadratic terms and an interaction term. To assess performance, we used leave-one-out cross-validation and adjusted for unequal sample sizes (for example, we weigh each population equally when computing the mean prediction accuracy).