An earlier onset for development of Major Depressive Disorder (Figure 3) and for developing an Anxiety Disorders (Figure 4) is also seen among high risk offspring. Major depressive disorder (MDD) and Anxiety Disorders diagnoses were based on a DSM-III (K-SADS) diagnosis if present before age 18 and based on a DSM-IV (CIDI) diagnosis for those over age 19. As may be seen, MDD affected approximately 25 % of the high risk offspring by age 21.
