with pathological symptoms in obsessive compulsive disorder (Bahramisharif et al., 2016; Treu et al., 2021; Yakubov et al., 2022), and in Parkinson’s disease (de Hemptinne et al., 2013; López-Azcárate et al., 2010; van Wijk et al., 2016; Yin et al., 2022). As research into cross frequency coupling in the brain has expanded over the past two decades, this initial interpretation has given way to more sophisticated models where changes in PAC strength have different effects depending on the neural circuits where they appear and their interaction with coherence of other within-frequency and cross-frequency manifestations of neural synchrony.
