An association has been found between a stimulus-elicited electrodermal response (hyporeactivity), as measured by skin conductivity, and SB in several studies (see Thorell47 for meta-analysis). Moreover, electrodermal activity during decision making seems to implicate key brain regions associated with SB (see below), such as the ventral and medial prefrontal cortices.48 Electrodermal reactivity is under genetic influence, with a heritability of ∼50% in healthy twins,49 and is state independent.50 In addition, an electrodermal response has been correlated with decision making in the Iowa gambling task in healthy subjects.51 Therefore, electrophysiological hyporesponsivity may be an endophenotype partially linked with poor decision-making abilities.
