Furthermore, our system provides visualization and instant annotation for detected variants. Using the circle plotting, important regulatory variants and its affected regions, as well as the intra/interchromosomal interactions related to variants, can be intuitively displayed. Although many tools, such as SeattleSeq, ANNOVAR (50) and ENSEMBL VEP (51), can help users retrieve sufficient variant annotations, the integrative function annotation of GWAS3D will benefit users for instant query and broader range of information. Therefore, besides the genomic mapping information of variant (such as information of gene and other genomic elements), we offered several direct links to the servers of GWASrap (40), RegulomeDB and UCSC ENCODE genome browser in the internal windows of GWAS3D.
