A polygenic score (PGS) for DSM-NicDep was significantly associated with DSM-5 tobacco use disorder in the European ancestry subset of the NESARC-III sample (beta = 0.07, SE = 0.02, p-value = 5.11e-3; Ncases = 4,205), as was a polygenic score for FTND (beta = 0.07, SE = 0.02, p-value = 3.11e-3). Results from item-level logistic regression models are shown in Figure 3. The DSM-NicDep PGS was associated with 6 of 11 criteria, as was the FTND PGS, although only 3 of these criteria were associated with both (TimeSpent, Problems, and Withdrawal). The FTND PGS was associated with 3 of the 4 FTND items, as expected, while the DSM-NicDep PGS was not associated with any FTND items. Failure to fulfill major role obligations (Fail) and Use of larger amounts or for longer than intended (Larger) were unrelated to both PGS after multiple testing correction. Despite these apparent disparities, estimates were not significantly different for the DSM-NicDep and FTND PGS.
