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Chunk #4 — Introduction

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Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
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by more than 3 orders of magnitude, as did the support in schizophrenia and bipolar disorder combined (P=4.1 ×10−13). Moreover, the evidence for association in replication samples (i.e. after exclusion of the discovery GWAS) was also genome wide significant, making rs1344706 in ZNF804A the most robustly supported common allele for schizophrenia reported to date. The strength of the findings also strongly support accumulating data that genetic risk for schizophrenia and bipolar disorder(12) overlap.