The two highly correlated SNPs rs2033195 and rs815611 are located on chromosome 5q33.2 near the genes microfibrillar-associated protein 3 isoform 1 (MFAP3) and GALNT10. MFAP3 is a microfibrillar protein, in which the microfibrils family acts to control tumor growth factor β bioavailability (33). GALNT10 encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferase involved in the synthesis of mucin-type oligosaccharides. GALNT10 is highly expressed in the central nervous system including the hypothalamus, thalamus, and amygdala (34). A related family member, GALNT2, is associated with high-density lipoprotein levels in European-ancestry GWAS (35,36). The close relationship between adiposity and lipid levels and the recent identification of central nervous system regulating adiposity loci makes GALNT10 a new potential candidate for regulation of adiposity.
