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Chunk #6 — Methods — The Religious order Study and the Memory and Aging Project (ROSMAP)

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A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research.
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Phenotypic data are accruing continually in ROS and MAP, and new phenotypes are periodically added to the routine clinical and pathological data collection. Thus, these new phenotypes become available as additional neuropathologic and other characterizations are performed. The ante-mortem and neuropathologic traits that are currently available can be browsed to assemble biological sample sets and data sets with the features desired by the investigator through the RADC Research Resource Sharing Hub (https://www.radc.rush.edu/). The high-dimensional data described in this manuscript can be obtained through the Accelerating Medicnes Partnership for Alzheimer’s disease (AMP-AD) Knowledge Portal that is supported by the National Institute of Aging (https://www.synapse.org/ampad). The phenotypes listed in Table 2 are available through this portal, and additional phenotypic data are available from RADC. Table 3 outlines the data available through the portal. Additional data are being produced and will be available through the portal as they complete quality control analyses.