Individuals from Banner were genotyped using Affymetrix Precision Medicine Array following the manufacturer’s protocol using DNA extracted from brain using Qiagen GenePure kit. We followed the same approach to quality control for the replication genotyping as was used for the discovery genotyping, including filtering based on data completeness, Hardy Weinberg equilibrium, MAF, and relatedness. Genotyping was also imputed to the 1000 Genome Project Phase 356 using the Michigan Imputation Server57 and SNPs with imputation R2 > 0.3 were retained. Finally, genotyping was filtered to only include sites on the LD reference panel provided by FUSION pipeline. After quality control, 152 subjects with proteomic and genetic data were included in our replication analyses. Among these, 87 were female and mean age at death was 85.
