A p-value of 0.025 was used to indicate study-wide significance. This is based on a multiple testing correction performed using the web-based software SNPSpD (Nyholt 2004), which takes into account the number of SNPs genotyped and linkage disequilibrium (LD) structure between them. Based on this test, the effective number of independent marker loci for our analyses was 2.0, resulting in the adjusted significance level of 0.05/2.0 = 0.025.
