below a filtering threshold from multiple testing adjustment. DESeq2 by default will choose a threshold that maximizes the number of genes found at a user-specified target FDR. In Figures 2A,B and 3, genes found in this way to be significant at an estimated FDR of 10% are depicted in red. Depending on the distribution of the mean normalized counts, the resulting increase in power can be substantial, sometimes making the difference in whether or not any differentially expressed genes are detected.
