Foroud and colleagues (2000) also analyzed the combined data set from the initial and replication samples using a more restricted definition of alcoholism as specified in the ICD–10. This restriction greatly reduced the number of sibling pairs in the comparison. The region on chromosome 1 provided the strongest evidence for a susceptibility gene in the combined sample. In addition, this new evaluation detected a region on chromosome 8 that was linked with the risk for alcoholism.
