Fig. 1A–D illustrates a grand mean S-transform time-frequency representation of the rare auditory oddball data in the frontal and parietal cortices obtained from B6 and D2 mice. Visual inspection of the time-frequency representation of the EROs in Fig. 1A–D show changes in ERO energy following presentation of the rare tone. As shown in Fig. 1A–B, an increase in ERO energy in the delta, theta and alpha/beta frequency bands is observed following presentation of the rare tone (vs. baseline). Changes in ERO energy were also observed following presentation of standard and noise tones (data not shown). Differences in ERO energy among the three auditory stimuli were observed in the frontal and parietal cortices when collapsing across B6 and D2 groups.