The statistical methodology used to examine the structure of abuse and dependence criteria was state of the art, and the data sets analyzed were large and based on standardized diagnostic procedures with good to excellent reliability and validity. However, these data sets, collected several years ago, were not designed to examine the reliability and validity of the DSM-5 substance use disorder diagnosis. Many studies showed that DSM-IV dependence was reliable and valid (5), suggesting that major components of the DSM-5 substance use disorders criteria are reliable as well. However, field trials using standard methodology to minimize information variance (213) are needed to provide information on the reliability of DSM-5 substance use disorder diagnosis that can be directly compared with DSM-IV (214), in addition to studies on the antecedent, concurrent, and predictive validity of DSM-5 substance use disorders relative to DSM-IV dependence.