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Chunk #3 — Background

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Five-Factor Model personality profiles of drug users.
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The present study adopts the well-validated Five-Factor Model of personality [11] which comprehensively covers the five major traits that define human personality across cultures [12,13]: Neuroticism (N), the tendency to experience negative emotions such as anxiety and depression; Extraversion (E), the tendency to be sociable, warm, active, assertive, cheerful, and in search of stimulation; Openness to Experience (O), the tendency to be imaginative, creative, unconventional, emotionally and artistically sensitive; Agreeableness (A), the dimension of interpersonal relations, characterized by altruism, trust, modesty, and cooperativeness; and Conscientiousness (C), a tendency to be organized, strong-willed, persistent, reliable, and a follower of rules and ethical principles. Each of these factors is hierarchically defined by specific facets, which can provide a more in-depth description of drug users' personalities.