Chunk #31 — Results — Performance of PRSs in the Women’s Health Initiative dataset

Source

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.

Embedded

yes

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For blood pressure traits, EA GWASs sample sizes were 70-74K individuals. There was no consistent pattern for the highest performing PRSs, but clearly the EA-based PRSs performed poorly. All PRSs explained less than 1% of the variance of blood pressure traits.