The ROS and MAP cohorts have been designed for data and sample sharing, and they have been at the forefront of large-scale omic data generation from the human brain and also of sharing such data through efforts such as the DREAM challenge10 and the AMP-AD research program funded by the National Institute of Aging. The data described in this report represent data that exist today and are available on Synapse. Numerous additional layers of data, including proteomic and metabolomic data, from tissue samples and purified cell populations are being produced and will become available as the data are finalized. We look forward to this large set of molecular and phenotypic data being repurposed by the neuroscience and other communities of researchers.