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Chunk #15 — Methods — 2.4 Statistical analyses — Gene-based test and pathway analysis

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Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study.
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A pathway analysis was carried out to determine which potential biological pathways could play a role in antisocial behavior. Pathway analysis was performed in the Ingenuity Pathway analysis program (Ingenuity Systems, release IPA6.0) using genes with a p-value below 0.01. Based on scientific literature, the Ingenuity database contains large amounts of up-to-date information concerning the localization, structure and biological functions of proteins and their interaction. Results were corrected for multiple testing using the Benjamini-Hochberg multiple testing correction as implemented in Ingenuity.