A GWAS on smoking traits from the MVP also included meta-analysis for smoking initiation and cessation from GSCAN28. The MVP EHR data also permitted analysis of nicotine use trajectories as a phenotype; 18 risk loci (e.g., neuronal growth regulator 1 (NEGR1) and cyclin and CBS domain divalent metal cation transport mediator 2 (CNNM2)) for this trait were identified in EUR. In addition to participants of European descent, this study has the merit of including comparatively large numbers of AAs and Latinx subjects, although only a few discoveries in those samples, still much smaller than the EUR sample, were reported.
