Study outcome measures by ACE count were number of adults with ACEs, ACE PAFs for the analyzed health conditions, ACE annual medical spending burden, ACE DALY annual economic burden, ACE total annual economic burden, and ACE per person (affected adult) total annual economic burden and lifetime economic burden. The ACE total annual economic burden was the sum of annual ACE DALY and ACE medical spending estimates. The ACE per person total annual economic burden was the ACE total annual economic burden divided by ACE prevalence (number of adults with ACEs). The ACE per person lifetime economic burden was the ACE per person total annual economic burden estimate applied to the number of years from age 18 to 79 years (current US life expectancy) and discounted 3% annually30 (a standard rate for valuing future health states) to present value. State-level calculation examples are reported in eTable 2 in Supplement 1 and all underlying state-level data are presented in eTables 3 to 6 in Supplement 1.
