For the dominant model (lys-lys + lys-glu vs. glu-glu) in genotypic analyses, overall the studies of alcohol abuse and dependence showed an overall P value of 1×10−44 with the ln (OR) of −1.51 (−1.72, −1.3) and OR of 0.22 (0.18, 0.27) under the random effects model (Table 1). The strong association did not change after the Mexican American subjects were excluded from the analysis (P = 2×10−44). Strong association was also found with alcoholic liver disease and alcoholics with cirrhosis and (or) pancreatitis with P value of 8×10−26 and OR of 0.21 (0.16, 0.29). No evidence of significant heterogeneity was found between studies. The combined studies of alcoholics without alcoholic liver disease, cirrhosis, or pancreatitis also produced strong association with P value of 1×10−37 and OR of 0.22 (0.17, 0.27). Furthermore, the consistently strong association was identified after the subjects of alcohol abuse or after the subjects of Mexican American were excluded with the P values of 5×10−35 and 2×10−37, respectively (Table 1).
