Also notable is the inclusion of rs1079597 (formerly known as DRD2 Taq1B) in the risk score. Rs1079597 is in linkage disequilibrium (i.e., correlated) with rs1800497 (formerly known as DRD2 Taq1A), a missense mutation located 10kb downstream of DRD2 in the ankyrin repeat and kinase domain containing 1(ANKK1) gene. rs1800497 has been previously suggested as a candidate polymorphism for substance use phenotypes (see meta-analyses by Munafó et al. 2007, 2009). rs1079597 and rs1800497 alleles have R-squared values with each other of 69.6% and 28.1% in European American and African samples, respectively (as estimated in SNAP, Johnson et al. 2008). While a recent report found that rs1079597 was not associated with cocaine dependence case-control status in a Spanish sample (Fernàndez-Castillo et al. 2010), it has been previously associated with nicotine withdrawal symptoms (Robinson et al. 2007), borderline personality traits (Nemoda et al. 2010), and Tourette syndrome (Herzberg et al. 2010).
