adult drug phenotypes [15]. A recent meta-analysis also found that this SNP was associated with adult alcohol use disorders [25]. Numerous SNPs in high LD (r2 ≥ 0.80) with rs279858 in non-Hispanic Caucasian and Hispanic populations (calculated using AMR and EUR 1000 Genomes Phase 1 populations in HaploReg v2; [49]) have been associated with adolescent conduct disorder [10, 11], and adult substance use disorders [17, 19, 50]. Thus, rs279858 is a reasonable proxy for these GABRA2 SNPs in both ethnic groups in the current study. This SNP also tags the commonly studied yin–yang haplotypes. Our use of a single, well-studied SNP within GABRA2 that tags other risk variants in GABRA2 is similar to methods of several other studies [10–12, 50].
