This second pattern gives rise to additional pathophysiological hypotheses. We found both single-SNP- and gene-level genetic evidence for overlap of REX with schizophrenia and other psychiatric traits based on LD score regression. Genetic correlation with schizophrenia –also observed in PGC-PTSD5 – is of particular interest, owing to the phenomenological similarities between REX and hallucinating. We might consider the main difference between these two experiences to be thought alienation in the case of hallucinations – the subject, in the case of a hallucination, cannot recognize the re-experienced thought or event as his or her own. Psychotic symptoms, per se, occur in some PTSD patients and, even more broadly, among individuals exposed to traumatic events.20 Auditory hallucinations occur not only in schizophrenia but in trauma-related disorders such as borderline personality disorder and, notably, PTSD.21 In context of these observed epidemiological associations between trauma exposure, PTSD, and psychosis, our findings of shared genetic risk for PTSD and schizophrenia should be further interrogated with the aim of revealing shared pathophysiological mechanisms and, possibly, new treatments. Regarding treatment, atypical antipsychotics have been used to treat
