The complement receptor 1 (CR1) gene, located on chromosome 1, encodes the receptor for C3b complement protein. CR1 and C3b can be involved in Abeta clearance and in the prevention of Abeta aggregation. Risk-factor mutations for LOAD have been found in CR1 (rs6656401 and rs3818361).155 The functional role of CR1 mutations in AD pathogenesis is not determined yet, and further studies are needed to find out the effect in Abeta deposition.155,156
