Existing studies of risk for psychopathology in the offspring of parents with substance use disorders (SUD) have largely focused on individual disorders (Hartman et al., 2006; Jacob et al., 2003; Xian et al., 2010; Scherrer et al., 2012, 2008; Marmorstein et al., 2009). While this line of research has identified a wide range of risk factors for specific disorders, we are not aware of previous examinations of the clustering of disorders into subtypes of comorbidity and the familial and environmental characteristics of those subtypes.