(Supplementary Figure 4b). We further examined expression of these transcripts in flow-sorted human β-cells from two separate individuals and documented β-cell expression for all but TMEM195, with SLC39A13, CRY2, GLIS3 and PROX1 being particularly highly expressed in these cells (Supplementary Figure 4c). Expression levels in metabolically relevant tissues for DGKB (β cells) and TMEM195 (liver) provide equally credible evidence for their respective candidacies as the causal gene at these loci. Furthermore, based on its relatively high expression levels in the β cell, SLC39A13 (neighboring gene to MADD) constitutes an intriguing candidate gene that may merit further investigation.
