prefrontal cortex of alcoholics (Fig. 11.8). Additionally, a greater number of exon features have fold-change values >2, which may suggest some gene or isoform reconstructions underestimate some of the differences occurring with alcohol dependence. Although individual exons cannot function solely on their own accord, these molecular units might serve as surrogate markers for differences in the functional transcript or gene product. Altered expression of individual exons may be of substantial interest, especially if these changes coincide with the site of activation, a site of intramolecule docking, or an alcohol-binding site for the fully formed protein substrate.
