It should be noted that for all the above stated results, comparisons were effectively between data collected on BXD 1–32 RI strains. Given the trend of high correlations between the studies on early BXD strain sets and data collected in this study, we can expect the same for further studies that utilize the complete BXD strain set. The robustness of behavioral measures such as thermal nociception and locomotor response assayed across multiple laboratories is evident from medium to high correlations. These results reiterate the usefulness of the BXD RI strain sets as a vital reference set with respect to its reliability across laboratories and time periods.