phenotype for all drugs of abuse. Historically, dopamine (DA) has been seen as a key neuromodulator driving reward processes, but an increasing amount of attention has been focused on other neuromodulatory and neurendocrine systems that may serve as more tenable sites for pharmacotherapy. Along these lines, it is often instructive to examine disorders that are frequently comorbid in the hopes of understanding a common underlying etiology, and in this regard, AUDs and cannabis use disorders (CUDs) share some similarity.
