The number of individuals utilized for the categorical phenotype ANYDEP was 1,770 (59% male). Summary results are provided only for genotyped individuals for both phenotypes. Nearly half the sample met DSM-IV criteria for at least one substance (ANYDEP, N=832, 47%). The COGA sample was ascertained through an alcohol dependent individual in treatment and families were selected for the highest density of alcohol dependent members; therefore, it was expected that there would be many individuals meeting criteria for alcohol dependence (40% in the full sample, but 84% of those who were dependent on alcohol and/or any other substance). In addition, 19% met criteria for cannabis dependence (with or without alcohol dependence). The rates for cocaine and opioid dependence were lower (11% and 4% respectively). There were 832 individuals that met criteria for at least one substance dependence diagnosis; of those, 312 (37.5%) endorsed at least two diagnoses. Alcohol and cannabis dependence were the most common (15%; Table 1).
