and the FTND questionnaires were administered to participants in the study of ND (2004–2014). Analysis of subjects with complete FTND data showed that of those reporting 1–10 CPD, 85% had a total score of 3 or less on the FTND, and <3% scored above 6 on the FTND. We included 4313 chip-typed low-quantity smokers (CPD<11) but without additional FTND items answered to the FTND 0–3 group for the meta analysis of common marker association with FTND.4 In our studies of R336C we included additional low-quantity smokers in this category, bringing the total number in the category to 18 184, with 15 527 chip-typed. The number of subjects per category were for R336C analysis:
