performed on all CBDB cases using a standardized paradigm. Details of tissue acquisition, handling, processing, dissection, clinical characterization, diagnoses, neuropathological examinations, RNA extraction and quality control measures were described previously23. The Brain and Tissue Bank cases were handled in a similar fashion (http://medschool.umaryland.edu/BTBank/ProtocolMethods.html). Toxicological analysis was performed on every case. Subjects with evidence of macro- or microscopic neuropathology, drug use, alcohol abuse, or psychiatric illness were excluded. Subject demographics and sample details are contained in Supplementary Table 7.
