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Chunk #39 — Methods — PRS-CS and PRS-CS-auto

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Polygenic prediction via Bayesian regression and continuous shrinkage priors.
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point; Fig. 3, middle panel), along with heavy, Cauchy-like tails (Fig. 3, lower panel). This prior is known as the horseshoe prior50, due to the horseshoe-shaped prior density on the shrinkage factor τj. As a increases, the prior on βj becomes less peaked at zero but the tails remain heavy. Finally, for fixed a and b, decreasing the global shrinkage parameter ϕ shifts the TPB prior from left to right, which imposes stronger shrinkage on the regression coefficients βj.