Sex differences in puff volume have been described among adult smokers [16]. In our sample, although the pattern of results differed across sex, there was no significant sex difference in any topography parameter in direct comparisons (data not shown). Differences have also been reported for adolescent nicotine metabolism between boys and girls using hormonal contraception [18]. Controlling for HC use accounted for a substantial amount of variance in our sample. Future research should examine the direct effects of HC use on smoking patterns in a larger sample. Controlling for the inverse relationship between BMI and metabolism did not affect results.
