Chunk #15 — Materials and Methods — Data Analysis

Source

Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.

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of the individual GWAS within each sample type (ALSPAC+FT12 and COGA+IASPSAD) and used these meta-analysis summary statistics to create additional polygenic scores in the two samples of the other type. Each of the four study samples was therefore used once as a discovery GWAS sample and four times as a validation sample for testing the value of the polygenic scores in predicting alcohol problems.