to 0 mM or chelating intracellular Ca2+ with EGTA or BAPTA (Fig 4C), are also able to induce FRB-like behaviour in TC neurons, in a similar way to that predicted by simulation studies to occur for cortical pyramidal neurons (Traub et al. 2003). This finding is consistent with experiments showing that disrupting Ca2+-induced Ca2+-release in TC neurons can also bring about a similar behaviour to FRB (Budde et al. 2000) and hints at a complex management of firing in these cells which may be potentially influenced by various regulatory systems which couple to the cyclic ADP ribose pathway (Budde et al. 2000), via increases in intracellular cyclic GMP (Graeff et al. 1998), or to protein kinase A (PKA) (Traub et al. 2003), via stimulation of cyclic AMP.
