with previous fine-mapping studies8,12) (Supplementary Table 10). When restricting the analysis to 16 genetically uncorrelated traits (|rg|<0.2; Methods and Supplementary Tables 11–12) we identified 1,626 PIP>0.95 SNP-trait pairs spanning 1,496 unique SNPs, with a median distance of 9kb between a PIP>0.95 SNP and the nearest lead GWAS SNP for the same trait (Supplementary Table 10). The 16 genetically uncorrelated traits included 5,314 genome-wide significant locus-trait pairs (defined by 1Mb windows around lead GWAS SNPs) harboring 0.28 PIP>0.95 SNPs per locus on average (Supplementary Table 13); 1,080 of the 5,314 locus-trait pairs (20%) harbored ≥1 PIP>0.95 SNP(s), harboring 1.37 PIP>0.95 SNPs on average (Supplementary Table 13). 150 of the 1,626 SNP-trait pairs identified by PolyFun + SuSiE PIP>0.95 (9.2%) did not lie within genome-wide significant loci, and 161 of the 1,626 SNP-trait pairs (9.9%) had P>5×10−8 (Supplementary Table 10).
