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Chunk #47 — Online Methods (Limit 3,000 words, at end of manuscript, currently 2,064) — Extension to Summary Statistics

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
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Concordance was also tested for the same nine European PGC-SCZ cohorts, across 12 neurological GTEx prediction databases. All correlations were significant (rho > 0.95, p < 2.2 × 10−16). There was a significant correlation between p-value concordance and case-control ratio (rho = 0.37, p = 7.606 × 10−15). 114 genes had discordant p-values between the two methods and were excluded from future analyses.