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Chunk #4 — RESULTS — Identification of loci associated with height

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Identification of ten loci associated with height highlights new biological pathways in human growth.
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ascertainment), a level of significance strongly suggestive of true association (Table 1; detailed association results and LD plots are given in Supplementary Table 7 and Supplementary Fig. 2 online, respectively)3. Of the three loci with P values between 5 × 10-7 and 5 × 10-8, two were confirmed in the accompanying manuscript18 (SH3GL3-ADAMTSL3 and CDK6), and one had strong independent evidence of association in the European American tall-short (USHT) panel (CHCHD7-RDHE2, P = 9 × 10-6; Table 1). This indicates that loci with P values in this range are at least enriched for loci with valid associations with height. In addition, four loci showed overall suggestive evidence (combined P < 5 × 10-6) of association with adult height (Table 1). Although SNP rs2730245 at the WDR60 locus has a combined P = 3 × 10-7, we chose to include this marker in our list of suggestive associations because, unlike the 12 loci in the top section of Table 1, this signal had a follow-up P > 0.05.