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Chunk #4 — Introduction

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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
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expression profiling of 22,184 transcripts in all four brain regions. Here we discuss the results of these experiments, particularly in the context of integrated datasets to define expression quantitative trait loci (eQTL) and CpG methylation quantitative trait loci (methQTL), where quantitative trait loci (QTL) are correlations between genetic variation within genomic region(s) (in this case single nucleotide polymorphisms) and a quantitative trait (DNA methylation or expression), and detailing differences and similarities across brain regions.