Consistent with our previous findings, the association of rs16969968 genotypes with abstinence depended upon treatment condition. Rs16969968 genotypes were associated with abstinence in the placebo group (X2=6.54, df=2, p=0.038), but not in the cNRT group (X2=2.55, df=2, p=0.28). The effect of cNRT differed across genotype groups (GG: OR=1.57, 95% CI=0.79–3.16, df=1, p= 0.20; GA: OR=4.45, 95% CI=2.21–8.98, df=1, p= 3.1×10−5; AA: OR=14.7, 95% CI=2.57–84.3, df=1, p= 0.0025). These results reflect a significant interaction between treatment (placebo versus cNRT) and rs16969968 genotypes (Table 1; Figure 1).
