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Chunk #14 — Materials and methods — EEG source functional connectivity analysis — ROIs

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Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration.
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The current implementation of eLORETA (Pascual-Marqui, 2007) uses a realistic head model (Fuchs et al., 2002) based on the MNI152 template, with the three-dimensional solution space restricted to the cortical gray matter and hippocampi, as determined by the probabilistic Talairach atlas (Lancaster et al., 2000). The intracerebral volume (eLORETA inverse solution space) is partitioned in 6239 voxels at 5 mm spatial resolution (i.e., cubic elements of 5 × 5× 5 mm). Anatomical labels corresponding to Brodmann areas are reported using neuroanatomical Montreal Neurological Institute space (MNI; Montreal, Quebec, Canada), converted to Talairach space (Brett et al., 2002). In order to identify intracerebral electrical sources and reduce the number of estimates, we chose a ROI-maker method (available in eLORETA) for the construction of the ROIs. Firstly, we selected 28 ROIs (14 for each hemisphere; see Supplementary Table 1), starting from 42 Brodmann Areas (BAs) in each hemisphere according to the anatomical definitions of BAs provided by eLORETA software package, based on the Talairach Daemon (http://www.talairach.org/). Secondly, we selected a single voxel as the centroid of each ROI, as this representative voxel