To capture all of the nominated cis-eQTL SNPs, genotype imputation was conducted using IMPUTE2 (49) with reference to all 1000 Genomes haplotype panels (50, 51). To avoid potential bias due to UHS cases and population controls being genotyped on different arrays, imputations were based on the intersection of SNPs available across all participants (52). Further details on quality control and imputation are provided in the Supplement.
