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Chunk #17 — 2. METHODS — 2.6. Specific substance dependence analyses

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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
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To examine whether substance-specific results remained consistent with a larger number of datasets, we used all datasets that had assessed each substance for additional interpretive tests, with the dependence diagnosis as outcome and additively coded rs1799971, sex, and age as explanatory variables.