We used an extended nature of nurture model to examine the pathways through which parental genotypes influenced offspring alcohol outcomes. All paths shown in Figure 1 were modeled simultaneously and the full results are presented in Supplementary Tables 4–7 for the AUDSx, MaxDrinks, Initiation, and Intoxication outcomes separately by ancestry. Descriptive statistics for each analytic sample are presented in Supplementary Tables 8–11. In what follows, we focus on the indirect pathways of primary interest: parental relationship discord and divorce as mediators of transmitted and nontransmitted parental and maternal alleles on offspring alcohol outcomes, and paternal and maternal alcohol use behaviors as mediators of the effects of transmitted and nontransmitted paternal and maternal alleles on offspring’s matched alcohol outcomes.
