Individuals with high-risk mild-to-moderate AUD were more likely to endorse a greater number of criteria than those with low-risk mild-to-moderate AUD (eg, 42.5% vs 6.8% endorsed 5 criteria). Even after accounting for the number of criteria endorsed, individuals with mild-to-moderate AUD who endorsed high-risk criteria were more likely to consume a greater number of drinks during heavy drinking episodes and periods of frequent drinking; endorse seeking help or treatment; meet criteria for other SUDs, MDD, and ASPD; and have lower theta EROs when compared with individuals with low-risk mild-to-moderate AUD (Table 2 and eTable 5 in Supplement 1). AUD PGS also distinguished between low-risk mild-to-moderate and severe AUD in the African American ancestry subsample (OR, 1.30; 95% CI, 1.09-1.56) (eTable 3 in Supplement 1). Notably, the high-risk mild-to-moderate group did not statistically differ from the severe AUD group on theta EROs or P300 amplitude after accounting for criterion count differences.
