The organizing framework designed for the study included constructs deemed to be essential to informed decision-making and engagement in health-related genetic research [4, 33–36] (Figure 2). In applying the framework in this study, the independent process variables were knowledge about genetics; beliefs regarding the benefits and risks of gene testing; perceptions regarding the utility of genetic testing; and involvement of health care providers in health care decisions. The dependent outcome variable was willingness to participate in health-related genetic research. More specifically, the organizing framework hypothesized the influence of knowledge about genetics; beliefs regarding benefits and risks of gene testing; perceptions regarding the utility of genetic testing; and directive and nondirective involvement of health care providers on decisions made relative to participation in health-related genetics research and willingness to participate in health-related genetic research.
